Screenshot

We’ve got a new chapter out from Bryan Jones and Robert Marc, Injury and Repair: Retinal Remodeling for the 2nd Edition of Encyclopedia of the Eye. (PDF here)

Abstract: Retinal remodeling is a collection of molecular and cellular revisions triggered by retinitis pigmentosa (RP), Usher syndrome, age-related macular degeneration (AMD), and likely glaucoma. These revisions include neuronal rewiring and neurotransmitter receptor reprogramming; neuritogenesis and synaptogenesis (chemical and electrical); self-signaling; neuronal migration; neuronal death; glial hypertrophy; altered glial gene expression; vascular remodeling; retinal pigmented epithelium (RPE) invasion and hyperpigmentation, and in the terminal stages, extensive proteinopathies. Metabolic and circuit revisions begin as soon as photoreceptor stress is initiated, and accelerate upon complete local photoreceptor loss. Retinal remodeling impacts the timing and potential outcomes of gene therapy, survival factor treatments, stem or progenitor cell implantation, retinal transplantation, and bionic implants.